Description

Semax 10 mg — ACTH-Derived Nootropic Peptide for Cognitive & Neuroprotective Research

Semax is a synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH 4–10), modified for enhanced stability and central nervous system activity. In preclinical research, Semax has been studied for its effects on cognitive performance, neuroprotection, neurotrophic signaling, and attention/memory pathways, with broad interest across cognitive neuroscience, stroke recovery models, and stress adaptation research.

What It Is

• Class: Synthetic heptapeptide nootropic / neuroprotective compound (ACTH 4–10 analog)
• Concept: A stabilized fragment of ACTH engineered for enhanced enzymatic resistance and CNS bioavailability, designed to engage neurotrophic and cognitive pathways without the steroidogenic effects of full-length ACTH.
• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Neurotrophic Signaling

• Research suggests upregulation of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) expression.
• Investigations into tyrosine kinase receptor (TrkB) signaling pathways linked to neuronal survival and plasticity.
• Studies on synaptic plasticity markers including long-term potentiation (LTP) in hippocampal research models.

Neurotransmitter & Cognitive Effects

• Research explores modulation of dopamine, serotonin, and acetylcholine systems in central nervous system models.
• Investigations into enkephalin degradation enzyme inhibition, prolonging endogenous opioid peptide activity.
• Studies on attention, learning, and memory consolidation in cognitive performance models.
• Examination of neuroprotective effects in models of cerebral ischemia, oxidative stress, and excitotoxicity.

Selected Research Highlights

• Stroke Recovery Research: Semax has been investigated in animal models of cerebral ischemia for effects on neurological recovery, infarct volume reduction, and post-stroke cognitive function.
• Cognitive Performance Studies: Animal research examining learning rate, memory consolidation, and attention markers under both normal and stressed conditions.
• Neuroprotection Investigations: Research on protective effects against oxidative stress, excitotoxic injury, and ischemia-reperfusion damage in neural tissue.
• BDNF Pathway Studies: Investigations into Semax’s role in upregulating neurotrophic factor expression in hippocampal and cortical research models.

Chemical & Handling Information

• Type: Synthetic heptapeptide (7-amino-acid sequence)
• Backbone: Met-Glu-His-Phe-Pro-Gly-Pro — a heptapeptide derived from ACTH (4–7) with a C-terminal Pro-Gly-Pro extension for enhanced enzymatic stability (exact sequence per lot specification)
• Appearance: White to off-white lyophilized powder
• Solubility: Reconstitutes readily in bacteriostatic water or sterile saline for laboratory preparation

Specifications

• Peptide: Semax
• Amount: 10 mg per vial
• Form: Lyophilized powder
• Purity: ≥99% (HPLC); COA per lot available
• Packaging: Sealed glass vials with rubber stopper and aluminum crimp seal, suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place, protected from light.
• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability, in accordance with standard laboratory SOPs.
• After reconstitution, store at 2–8 °C for short-term laboratory use (typically up to 30 days).
• For long-term storage of reconstituted material, aliquot and freeze at −20 °C or below.
• Avoid repeated freeze-thaw cycles, which can degrade peptide integrity.

Research Use Disclaimer

This product is sold strictly for laboratory research use only. Not intended for human or animal consumption. Not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease or condition. Customers are solely responsible for the lawful handling, storage, and use of this product in accordance with all applicable laws and regulations.