Description

Selank 10 mg — Synthetic Anxiolytic Peptide for Cognitive & Stress Response Research

Selank is a synthetic heptapeptide derived from the immunomodulatory peptide tuftsin, developed as a research tool for investigating anxiolytic (anti-anxiety) and nootropic pathways. In preclinical research, Selank has been studied for its effects on stress response modulation, anxiety-related behavior, cognitive performance, immune signaling, and neurotransmitter balance, with particular interest in its non-sedative profile relative to traditional anxiolytic compounds.

What It Is

• Class: Synthetic heptapeptide anxiolytic / nootropic (tuftsin analog)
• Concept: A stabilized, modified analog of tuftsin engineered for resistance to enzymatic degradation, designed to engage central nervous system pathways involved in anxiety and cognition without the sedation or dependency profile of GABAergic anxiolytics.
• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Neurotransmitter Modulation

• Research suggests modulation of GABA receptor signaling through non-direct pathways.
• Investigations into effects on serotonin (5-HT) and dopamine turnover in central nervous system models.
• Studies on brain-derived neurotrophic factor (BDNF) expression in cognitive and stress-related research.

Stress Response & Immune Pathways

• Research explores effects on cortisol regulation and hypothalamic-pituitary-adrenal (HPA) axis modulation.
• Investigations into enkephalin degradation enzyme inhibition, prolonging endogenous opioid peptide activity.
• Studies on cytokine balance, including effects on interleukin profiles in immune-cell research.
• Examination of anti-anxiety behavioral markers in standard preclinical anxiety models (elevated plus-maze, open field tests).

Selected Research Highlights

• Anxiety Model Studies: Selank has been investigated in classical preclinical anxiety paradigms with effects reported to be comparable to benzodiazepine references, but without observed sedation or motor impairment.
• Cognitive Performance Research: Animal studies examining effects on learning, memory consolidation, and attention markers under stress conditions.
• Stress Adaptation: Investigations into chronic stress models, including effects on stress-induced behavioral and biochemical changes.
• Immune-Neural Interactions: Research on Selank’s dual role at the intersection of immune signaling and central nervous system modulation, building on its tuftsin-derived origins.

Chemical & Handling Information

• Type: Synthetic heptapeptide (7-amino-acid sequence)
• Backbone: Thr-Lys-Pro-Arg-Pro-Gly-Pro — a heptapeptide derived from tuftsin (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro extension for enhanced enzymatic stability (exact sequence per lot specification)
• Appearance: White to off-white lyophilized powder
• Solubility: Reconstitutes readily in bacteriostatic water or sterile saline for laboratory preparation

Specifications

• Peptide: Selank
• Amount: 10 mg per vial
• Form: Lyophilized powder
• Purity: ≥99% (HPLC); COA per lot available
• Packaging: Sealed glass vials with rubber stopper and aluminum crimp seal, suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place, protected from light.
• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability, in accordance with standard laboratory SOPs.
• After reconstitution, store at 2–8 °C for short-term laboratory use (typically up to 30 days).
• For long-term storage of reconstituted material, aliquot and freeze at −20 °C or below.
• Avoid repeated freeze-thaw cycles, which can degrade peptide integrity.

Research Use Disclaimer

This product is sold strictly for laboratory research use only. Not intended for human or animal consumption. Not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease or condition. Customers are solely responsible for the lawful handling, storage, and use of this product in accordance with all applicable laws and regulations.