Description

Melanotan II 10 mg — Synthetic Melanocortin Agonist for Pigmentation & Receptor Research

Melanotan II is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH), designed as a non-selective melanocortin receptor agonist. In preclinical research, Melanotan II has been studied for its effects on melanogenesis (pigmentation pathways), melanocortin receptor signaling, appetite regulation, and sexual function pathways through its activity at multiple melanocortin receptor subtypes (MC1R, MC3R, MC4R, MC5R).

What It Is

• Class: Non-selective melanocortin receptor agonist (cyclic α-MSH analog)
• Concept: A cyclized, modified analog of α-MSH engineered for greater stability and receptor affinity, allowing research into multiple melanocortin-mediated pathways from a single compound.
• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Melanocortin Receptor Activation

• Activates MC1R (melanocortin-1 receptor) on melanocytes, stimulating eumelanin synthesis.
• Engages MC3R and MC4R in central nervous system pathways involved in energy balance and feeding behavior.
• Binds MC5R, expressed in exocrine glands and peripheral tissues, with research interest in sebaceous and immune-modulatory effects.

Downstream Physiological Effects

• Research explores stimulation of melanogenesis and increased melanin production in dermatology models.
• Investigations into appetite suppression