Description

SS-31 50 mg — Mitochondrial-Targeted Peptide for Cellular Energy & Longevity Research

SS-31 (also known as Elamipretide or MTP-131) is a synthetic tetrapeptide designed to selectively concentrate in the inner mitochondrial membrane by binding to cardiolipin, a phospholipid unique to mitochondria. In preclinical research, SS-31 has been extensively studied for its effects on mitochondrial function, cellular energy production (ATP), oxidative stress reduction, and tissue-level protection in models of cardiac dysfunction, neurodegeneration, kidney injury, and aging.

What It Is

• Class: Mitochondrial-targeted tetrapeptide; cardiolipin-binding peptide
• Concept: Selectively accumulates in the inner mitochondrial membrane (1,000–5,000× higher concentration than cytoplasm in research models), where it stabilizes cardiolipin and supports mitochondrial structural integrity and electron transport chain efficiency.
• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Cardiolipin Binding & Mitochondrial Stabilization

• Selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing its structural conformation.
• Supports cristae architecture and electron transport chain organization.
• Research suggests improved ATP production efficiency in dysfunctional mitochondria.

Oxidative Stress & Cellular Protection

• Investigations into reduction of reactive oxygen species (ROS) generation at the mitochondrial membrane.
• Research on protection against cardiolipin peroxidation and resulting membrane dysfunction.
• Studies on prevention of cytochrome c release and apoptotic signaling.
• Examination of effects on mitochondrial permeability transition pore (mPTP) opening under stress conditions.

Selected Research Highlights

• Cardiac Research: SS-31 has been investigated in models of heart failure, ischemia-reperfusion injury, and cardiomyopathy, with reported effects on cardiac mitochondrial function and contractile performance.
• Aging & Longevity Studies: Animal research examining effects on age-related mitochondrial decline, skeletal muscle function, and cellular energy metabolism in aged subjects.
• Kidney Injury Research: Studies on acute kidney injury models, including ischemia-reperfusion and toxin-induced damage, with focus on renal mitochondrial preservation.
• Neurodegeneration Investigations: Research exploring effects in models of Alzheimer’s, Parkinson’s, and other neurodegenerative conditions where mitochondrial dysfunction is implicated.

Chemical & Handling Information

• Type: Synthetic tetrapeptide (4-amino-acid sequence)
• Backbone: D-Arg-Dmt-Lys-Phe-NH₂ — features a 2′,6′-dimethyltyrosine (Dmt) residue and alternating cationic/aromatic structure that enables cell penetration and mitochondrial targeting (exact sequence per lot specification)
• Appearance: White to off-white lyophilized powder
• Solubility: Reconstitutes readily in bacteriostatic water or sterile saline for laboratory preparation

Specifications

• Peptide: SS-31 (Elamipretide / MTP-131)
• Amount: 50 mg per vial
• Form: Lyophilized powder
• Purity: ≥99% (HPLC); COA per lot available
• Packaging: Sealed glass vials with rubber stopper and aluminum crimp seal, suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place, protected from light.
• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability, in accordance with standard laboratory SOPs.
• After reconstitution, store at 2–8 °C for short-term laboratory use (typically up to 30 days).
• For long-term storage of reconstituted material, aliquot and freeze at −20 °C or below.
• Avoid repeated freeze-thaw cycles, which can degrade peptide integrity.

Research Use Disclaimer

This product is sold strictly for laboratory research use only. Not intended for human or animal consumption. Not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease or condition. Customers are solely responsible for the lawful handling, storage, and use of this product in accordance with all applicable laws and regulations.