Description

NAD+ 1000 mg — Nicotinamide Adenine Dinucleotide for Cellular Energy & Longevity Research

NAD+ (Nicotinamide Adenine Dinucleotide, oxidized form) is a fundamental coenzyme found in every living cell, central to cellular energy metabolism, DNA repair, and longevity-related signaling pathways. In preclinical research, NAD+ has been extensively studied for its effects on mitochondrial function, sirtuin activation, cellular aging markers, DNA repair, and metabolic health, making it one of the most heavily investigated compounds in modern longevity and aging research.

What It Is

• Class: Pyridine nucleotide coenzyme; essential cellular cofactor
• Concept: A central metabolic coenzyme that cycles between oxidized (NAD+) and reduced (NADH) forms during cellular energy production, also serving as a substrate for sirtuin enzymes, PARPs, and CD38 in age-related signaling pathways.
• Format: Research-grade NAD+ supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Cellular Energy Metabolism

• Serves as the central electron carrier in glycolysis, the citric acid cycle, and oxidative phosphorylation.
• Required for ATP production in mitochondrial electron transport chain function.
• Modulates redox balance through the NAD+/NADH ratio, a key marker of metabolic state.

Sirtuin & Longevity Pathways

• Acts as a required substrate for sirtuin enzymes (SIRT1–SIRT7), which regulate gene expression, DNA repair, and metabolic signaling.
• Research suggests influence on SIRT1 and SIRT3 activity, linked to mitochondrial biogenesis and stress resistance.
• Supports PARP (poly-ADP-ribose polymerase) activity in DNA damage response and repair.
• Substrate for CD38 and other NAD+-consuming enzymes involved in immune signaling and calcium regulation.

Cellular Aging Markers

• Research explores declining NAD+ levels as a marker of cellular aging and metabolic dysfunction.
• Investigations into NAD+ restoration effects on mitochondrial function and cellular respiration in aged models.
• Studies on connections between NAD+ availability and autophagy, senescence markers, and inflammatory signaling.

Selected Research Highlights

• Longevity Studies: NAD+ has been extensively investigated for effects on lifespan and healthspan markers in model organisms, including studies on age-related decline in NAD+ levels across tissues.
• Mitochondrial Function Research: Animal studies examining effects on mitochondrial biogenesis, ATP production capacity, and oxidative phosphorylation in aged and metabolically stressed models.
• Neurodegenerative Investigations: Research on NAD+ pathways in Alzheimer’s, Parkinson’s, and other neurodegenerative models where mitochondrial and metabolic dysfunction are implicated.
• Metabolic Health Studies: Investigations into effects on insulin sensitivity, glucose metabolism, and body composition in diet-induced obesity and metabolic dysfunction research.

Chemical & Handling Information

• Type: Pyridine nucleotide coenzyme
• Structure: Nicotinamide Adenine Dinucleotide (oxidized form) — a dinucleotide composed of nicotinamide and adenine linked through phosphate groups (exact specification per lot)
• Appearance: White to off-white lyophilized powder
• Solubility: Highly water-soluble; reconstitutes readily in bacteriostatic water or sterile saline for laboratory preparation

Specifications

• Compound: NAD+ (Nicotinamide Adenine Dinucleotide, oxidized form)
• Amount: 1000 mg per vial
• Form: Lyophilized powder
• Purity: ≥99% (HPLC); COA per lot available
• Packaging: Sealed glass vials with rubber stopper and aluminum crimp seal, suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place, protected from light.
• NAD+ is particularly sensitive to heat, light, and moisture — minimize exposure during handling.
• Refrigeration or freezing of the lyophilized compound is strongly recommended for extended stability, in accordance with standard laboratory SOPs.
• After reconstitution, store at 2–8 °C for short-term laboratory use; NAD+ degrades faster in solution than in lyophilized form, so use promptly.
• For long-term storage of reconstituted material, aliquot and freeze at −20 °C or below; avoid repeated freeze-thaw cycles.

Research Use Disclaimer

This product is sold strictly for laboratory research use only. Not intended for human or animal consumption. Not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease or condition. Customers are solely responsible for the lawful handling, storage, and use of this product in accordance with all applicable laws and regulations.