Description

TB-500 10 mg — Thymosin Beta-4 Fragment for Tissue Repair & Cellular Migration Research

TB-500 is a synthetic peptide fragment derived from thymosin beta-4 (TB4), a naturally occurring 43-amino-acid protein involved in tissue repair, cellular migration, and actin regulation. The synthetic TB-500 fragment captures the most studied functional region of TB4, retaining its activity while offering improved research handling. In preclinical research, TB-500 has been extensively studied for its effects on wound healing, angiogenesis, cellular migration, muscle and tendon recovery, and inflammatory modulation.

What It Is

• Class: Synthetic peptide fragment of thymosin beta-4 (TB4)
• Concept: A focused fragment of the parent TB4 protein that retains its key functional activity — sequestering G-actin and supporting cellular migration to sites of injury — while being more practical to synthesize and handle in research preparations.
• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Actin Cytoskeleton Modulation

• Sequesters G-actin (monomeric actin), regulating the available pool for filament assembly.
• Influences F-actin polymerization dynamics, supporting controlled cytoskeletal remodeling.
• Supports cellular migration to sites of injury through enhanced cytoskeletal flexibility.

Tissue Repair & Vascular Effects

• Research explores endothelial cell proliferation and capillary network formation (angiogenesis).
• Investigations into accelerated wound closure across dermal, corneal, and connective-tissue injury models.
• Studies on anti-inflammatory effects at sites of acute and chronic injury.
• Examination of collagen deposition and remodeling in scar tissue formation research.

Selected Research Highlights

• Wound Healing Studies: TB-500 has been investigated for accelerated dermal wound closure, corneal repair, and burn wound healing in multiple research models.
• Cardiac Research: Studies on cardiac tissue repair following ischemic injury, including effects on epicardial progenitor cell mobilization and infarct remodeling.
• Muscle & Tendon Recovery: Animal research examining recovery from muscle injury, tendon damage, and exercise-induced tissue stress.
• Neuroprotection Investigations: Research exploring effects on neural injury models, including traumatic brain injury and peripheral nerve recovery.

Chemical & Handling Information

• Type: Synthetic peptide fragment of thymosin beta-4
• Backbone: Synthetic fragment corresponding to the active actin-binding region of TB4, commonly the 17-amino-acid central sequence (LKKTETQ region); exact sequence per lot specification
• Appearance: White to off-white lyophilized powder
• Solubility: Reconstitutes readily in bacteriostatic water or sterile saline for laboratory preparation

Specifications

• Peptide: TB-500 (Thymosin Beta-4 Fragment)
• Amount: 10 mg per vial
• Form: Lyophilized powder
• Purity: ≥99% (HPLC); COA per lot available
• Packaging: Sealed glass vials with rubber stopper and aluminum crimp seal, suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place, protected from light.
• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability, in accordance with standard laboratory SOPs.
• After reconstitution, store at 2–8 °C for short-term laboratory use (typically up to 30 days).
• For long-term storage of reconstituted material, aliquot and freeze at −20 °C or below.
• Avoid repeated freeze-thaw cycles, which can degrade peptide integrity.

Research Use Disclaimer

This product is sold strictly for laboratory research use only. Not intended for human or animal consumption. Not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease or condition. Customers are solely responsible for the lawful handling, storage, and use of this product in accordance with all applicable laws and regulations.