Description

MOTS-c 40 mg — Mitochondrial-Derived Peptide for Metabolic, Exercise & Longevity Research

MOTS-c (Mitochondrial Open Reading Frame of the Twelve S rRNA type-c) is a 16-amino-acid mitochondrial-derived peptide (MDP) encoded within the mitochondrial DNA itself — a rare class of bioactive peptides originating from outside the nuclear genome. In preclinical research, MOTS-c has been studied for its effects on metabolic homeostasis, insulin sensitivity, exercise capacity, body weight regulation, and cellular stress response, with broad interest in exercise physiology, metabolic syndrome, and longevity research.

What It Is

• Class: Mitochondrial-derived peptide (MDP); 16-amino-acid bioactive peptide
• Concept: A peptide encoded by the mitochondrial genome that functions as a signaling molecule influencing metabolic regulation, exercise adaptation, and cellular stress response — acting as a communication link between mitochondrial status and whole-body metabolism.
• Format: Research-grade synthetic peptide supplied as a lyophilized powder.

Proposed Mechanisms (Preclinical)

Metabolic Signaling

• Research suggests activation of AMP-activated protein kinase (AMPK), a central energy sensor in cellular metabolism.
• Influences glucose uptake and insulin sensitivity in skeletal muscle and adipose tissue models.
• Investigations into modulation of the folate-methionine cycle and one-carbon metabolism.

Exercise & Mitochondrial Adaptation

• Research explores effects on exercise capacity, endurance markers, and muscle fatigue resistance.
• Investigations into mitochondrial biogenesis and oxidative metabolism in skeletal muscle.
• Studies on circulating MOTS-c levels as a marker of mitochondrial health that declines with age.
• Examination of stress-response signaling linking mitochondrial status to systemic metabolic adaptation.

Selected Research Highlights

• Insulin Sensitivity Studies: MOTS-c has been investigated in diet-induced obesity and insulin resistance models, with reported effects on glucose handling and metabolic markers.
• Exercise Physiology Research: Animal studies examining effects on running endurance, exercise capacity, and skeletal muscle adaptation to physical stress.
• Aging Research: Investigations into age-related decline in circulating MOTS-c and effects of restoration on metabolic and physical performance markers.
• Body Composition Studies: Research on effects on body weight, fat mass, and metabolic flexibility in animal models of obesity and metabolic dysfunction.

Chemical & Handling Information

• Type: Synthetic mitochondrial-derived peptide
• Backbone: 16-amino-acid sequence encoded within the mitochondrial 12S rRNA gene region (exact sequence per lot specification)
• Appearance: White to off-white lyophilized powder
• Solubility: Reconstitutes readily in bacteriostatic water or sterile saline for laboratory preparation

Specifications

• Peptide: MOTS-c
• Amount: 10 mg per vial
• Form: Lyophilized powder
• Purity: ≥99% (HPLC); COA per lot available
• Packaging: Sealed glass vials with rubber stopper and aluminum crimp seal, suitable for standard laboratory handling

Storage & Stability

• Store lyophilized vials in a cool, dry place, protected from light.
• Refrigeration or freezing of the lyophilized peptide is recommended for extended stability, in accordance with standard laboratory SOPs.
• After reconstitution, store at 2–8 °C for short-term laboratory use (typically up to 30 days).
• For long-term storage of reconstituted material, aliquot and freeze at −20 °C or below.
• Avoid repeated freeze-thaw cycles, which can degrade peptide integrity.

Research Use Disclaimer

This product is sold strictly for laboratory research use only. Not intended for human or animal consumption. Not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease or condition. Customers are solely responsible for the lawful handling, storage, and use of this product in accordance with all applicable laws and regulations.